Synthesis and biological evaluation of a novel cardiolipin affinity matrix.
نویسندگان
چکیده
Cardiolipin (1) is a dimeric phospholipid found in the mitochondrial membranes of both plants and animals. In order to understand better its role, we report the preparation of an immobilised analogue (2) using phosphoramidite chemistry; the probe has been used successfully to bind a recombinant protein containing a cardiolipin-binding domain.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 7 18 شماره
صفحات -
تاریخ انتشار 2009